Treatment
Figure 2. Prevention of Stroke in Nonvalvular Atrial Fibrillation
Ischemic stroke
or TIA
High Risk
All
(I-A)
All
(I-A)
Moderate Risk
Low Risk
All
(I-A)
Many
(I-A)
Some
(I-A)
Alternate
(IIb-B)
Clopidogrel
Warfarin
(INR - 2.0-3.0)
+
Aspirin
Apixaban
5 mg bid
Alternatea
(I-B)
Alternateb
(I-B)
Dabigatran
150 mg bid
Alternatec
(IIa-B)
Rivaroxaban
20 mg/d
CHADS2 ≥1, ClcCr ≥25 mL/min, only one of these: (I-B)
• Age ≥80
• Weight <60 kg
• Creatinine ≥1.5 mg/dL
b
CHADS2 ≥1, normal heart valves, CrCl ≥15 mL/min, normal baseline clotting
c
CHADS2 ≥2 OR systemic embolization, CrCl ≥15 mL/min
a
