Key Points
2
➤ Obtain a lipid panel in adults with endocrine disorders to assess
triglyceride (TG) levels and to calculate LDL cholesterol (LDL-C).
➤ Treat adults with type 2 diabetes (T2D) and other cardiovascular (CV) risk
factors with a statin in addition to lifestyle modifications, aiming for an
LDL-C goal of <70 mg/dL.
➤ Consider statin therapy, irrespective of the CV risk score, in adults with
type 1 diabetes who are age 40 years and older, or have a history of
diabetes of at least 20 years, or either microvascular complications,
chronic kidney disease (CKD) stages 1-4, or obesity.
➤ Rule out hypothyroidism in patients with hyperlipidemia before treatment
with lipid lowering medications. In patients with hypothyroidism re-
evaluate the lipid profile when the patient is euthyroid.
➤ Consider statin therapy as adjunct to lifestyle modifications in adults
with persistent endogenous Cushing's syndrome or adults taking chronic
glucocorticoid therapy above replacement levels.
➤ For treatment of dyslipidemia in post-menopausal women, use statins,
rather than hormone therapy, because statins reduce atherosclerotic
cardiovascular disease (ASCVD).
➤ Evaluate and treat lipids and other CV risk factors in women who enter
menopause early (before the age of 40-45 years).
Assessment
1. Screening and Cardiovascular Disease Risk Assessment
Measurement of Lipids
➤ 1.1 In adults with endocrine disorders, we recommend a lipid panel for the
assessment of TG levels and for calculating LDL-C. (1|⊕⊕⊕
)
Technical Remarks:
▶ Non-fasting lipid panels are acceptable for initial screening.
▶ If TG levels are elevated or if genetic dyslipidemia is suspected, repeat a fasting lipid
panel.
▶ If lipoprotein(a) [Lp(a)] levels are measured, fasting or non-fasting samples can be
obtained.
