Prostate Cancer Treatment Algorithm
Localized
Pa ent
Popula on
Newly
Diagnosed
Cura ve intent: RT, RP, AS
Non-cura ve intent:
Observa on, ADT
Metasta c
Asterisk (*) indicates with con nuous testosterone suppression, with or without
denosumab or zoledronic acid.
Treatment Strategy
mCRPC*
Minimal/no symptoms:
Sipuleucel-T, Enzalutamide,
Abiraterone, Clinical Trial, Docetaxel
Symptoma c Post-Docetaxel:
Cabazitaxel, Enzalutamide, Abiraterone,
Ra-223, Clinical Trial
Symptoma c Pre-Docetaxel:
Docetaxel, Enzalutamide,
Abiraterone, Clinical Trial
ADT ± Docetaxel
or
ADT ± Abiraterone
Metasta c
Loca on
Clinical Trials
Non-
metasta c
CRPC
Recurrent/
ADT-Naïve
Salvage Therapy,
(e.g., RT)
Biochemical
only
Localized
Metasta c
