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Table 11. Hormone Regimens in Transgender Persons
Transgender females
a
Estrogen
Oral
Estradiol 2.0–6.0 mg/d
Transdermal
Estradiol transdermal patch
(New patch placed every 3–5 d)
0.025–0.2 mg/d
Parenteral
Estradiol valerate or cypionate 5–30 mg IM every 2 wk
2–10 mg IM every week
Anti-androgens
Spironolactone 100–300 mg/d
Cyproterone acetate
b
25–50 mg/d
GnRH agonist 3.75 mg SQ (SC) monthly
11.25 mg SQ (SC) 3-monthly
Transgender males
Testosterone
Parenteral testosterone
Testosterone enanthate or cypionate 100–200 mg SQ (IM) every 2 wk or
SQ (SC) 50% per week
Testosterone undecanoate
c
1000 mg every 12 wk
Transdermal testosterone
Testosterone gel 1.6%
d
50–100 mg/d
Testosterone transdermal patch 2.5–7.5 mg/d
Abbreviations: IM, intramuscularly; SQ, sequentially; SC, subcutaneously
a
Estrogens used with or without antiandrogens or GnRH agonist.
b
Not available in the United States.
c
One thousand milligrams initially followed by an injection at 6 wk then at 12-wk intervals.
d
Avoid cutaneous transfer to other individuals.
