Grading System Strength of Recommendation
Grade 1 = stronga
Grade 2 = weakb a
A = high
Quality of Evidence B = moderate b Grade 2 suggests that individual patient values may lead to different choices. C = low
Grade 1 recommendations are strong and indicate that the benefits do, or do not, outweigh risks, burden, and costs.
Abbreviations bid, twice a day; ClCr
GI, gastrointestinal; HCL, hydrochloric acid; HIV, human immunodeficiency virus; INR, international normalized ratio; IRP, international reference preparation; ISI, international sensitivity index; IV, intravenous; MNPT, mean normal prothrombin time; PCC, prothrombin complex concentrate; POC, point of care; PT, prothrombin time; PTR, prothrombin time ratio; VKA, vitamin K antagonist
, creatinine clearance; CNS, central nervous system; D/C, discontinue;
Source Ageno W, Gallus AS, Wittkowsky A, Crowther M, Hylek EM, Palareti G. Oral anticoagulant therapy: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of
Chest Physicians Evidence-Based Clinical Practice Guidelines. Chest. 2012;141(2 Suppl): e44S-e88S. Holbrook A, Schulman S, Witt DM, Vanvik PO, Fish J, Kovacs MJ, Svensson PJ, Veenstra DL, Crowther M, Guyatt GH. Evidence-based management of anticoagulant therapy: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines. Chest. 2012;141(2 Suppl):e152S-e184S.
