Treatment
Table 3. Antimicrobials Frequently Used (continued) Drug (Brand)
Dose
Cephalosporins Cefepime (Maxipime® Cefotaxime (Claforan® Cefoxitin (Mefoxin®
)
Ceſtazidime (Ceptaz®
, Fortaz® )
Ceſtriaxone (Rocephin® Cefuroxime (Zinacef ® Cephalexin (Keflex® Cefazolin (Ancef ® Fluoroquinolones
) , Kefzol®
Ciprofloxacin (Cipro®
)
Levofloxacin (Levaquin® Moxifloxacin (Avelox®
)
Miscellaneous Aztreonam (Azactam® Clindamycin (Cleocin®
others) ) )
) ,
Daptomycin (Cubicin® Linezolid (Zyvox® Tigecycline (Tygacil® Vancomycin Polymyxin B
Colistimethate (Coly-Mycin M®
)
Echinocandins Anidulafungin (Eraxis® Caspofungin (Cancidas®
Micafungin (Mycamine®
Triazoles Fluconazole (Diflucan® Itraconazole (Sporanox® Posaconazole (Noxafil® Voriconazole (Vfend®
) b Adjust for renal impairment. 9 ) ) ) )
) )
) ) ) ) ) ) )
1-2 g IV/IM q8-12h; Children: 50 mg/kg q8hb IV, IM ≤ 2 gm q4h; Children: 50-180 mg/kg dailyb IV 1-2 gm q6-8h; Children ≥ 3 mos: 30-40 mg/kg q6-8h
IV, IM ≥ 12 years: 500 mg - 1 gm q8h; Children (Fortaz®
only): 30-50 mg/kg IV q8-12hb
IV, IM Adult: 1-2 gm daily; Children: 50-75 mg/kg q12h IV, IM ≤ 3 gm q8h; Children > 3 mos: 50-240 mg/kg/db PO Adult: 1-4 gm/day; Children: 25-100 mg/kg IV 0.5-1.5 gm q6-8hb
PO, IV 500-750 mg q12h; Children: 6-10 mg/kg IV q8h
PO, IV 250-750 mg q24h PO, IV 400 mg q24h
1-2 gm q6-8h; Children: 30 mg/kg q6-8hb
IV, IM, PO 0.6-4.8 gm/day; Children: 20-40 mg/kg/day
IV 4 mg/kg q24hb
PO, IV 600 mg q12h; 10 mg/kg q8h IV 100 mg, then 50 mg q12h
IV 500 mg q6h OR 1 gm q12h; Children: 10 mg/kg q6hb 15,000 to 25,000 units/kg/day IVb 2.5-5 mg/kg/day in 2 to 4 divided dosesb
200 mg load, then 100 mg daily
70 mg load, then 50 mg daily; Children: 70 mg/m2 load, then 5 mg/m2 daily
100 mg daily 400 mg daily (6-12 mg/kg) dailyb
IV or PO 200 mg bid x 4 doses, then 200 mg dailyb PO (oral suspension) ≥ 13 yrs: 200 mg tid - 400 mg bid
IV 6 mg/kg (or 400 mg) q12h x 2 doses, then 4 mg/kg (or 200-300 mg) q12h; PO 200 mg q12h
