Grading System for Recommendations Category/Grade
Definition
Strength of Recommendation A B
C D E
Directly based on category I evidence
Directly based on category II evidence or extrapolated from category I evidence
Directly based on category III evidence or extrapolated from category I or II evidence
Directly based on category IV evidence or extrapolated from category I, II, or III evidence
Based on consensus of the Joint Task Force on Practice Parameters
Abbreviations ACE, angiotensin-converting enzyme; ADR, adverse drug reaction; AERD, aspirin-exacerbated respiratory disease; ARB, angiotensin receptor blocker; COX, cyclooxygenase; DILE, drug-induced lupus erythematosus; DMARDs, disease-modifying antirheumatic drugs; DRESS, drug rash with eosinophilia and systemic symptoms; FEV1
forced expiratory volume in 1 second; HAART, highly active antiretroviral therapy; HIV, human immunodeficiency virus; IgE, immunoglobulin E; NSAIDs, nonsteroidal anti-inflammatory drugs; RCM, radiocontrast media; SJS, Stevens-Johnson syndrome; SLE, systemic lupus erythematosus; TEN, toxic epidermal necrolysis; TMP-SMX, trimethoprim-sulfamethoxazole; TNF, tumor necrosis factor; TRALI, transfusion-related acute lung injury
,
Source Joint Task Force on Practice Parameters; American Academy of Allergy, Asthma and Immunology; American College of Allergy, Asthma and Immunology; Joint Council of Allergy, Asthma and Immunology. Drug allergy: an updated practice parameter. Ann Allergy Asthma Immunol. 2010;105(4):259-273.
Disclaimer
This Guideline attempts to define principles of practice that should produce high-quality patient care. It is applicable to specialists, primary care, and providers at all levels. This Guideline should not be considered exclusive of other methods of care reasonably directed at obtaining the same results. The ultimate judgment concerning the propriety of any course of conduct must be made by the clinician aſter consideration of each individual patient situation. Neither IGC, the medical associations, nor the authors endorse any product or service associated with the distributor of this clinical reference tool.
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