Treatment
Table 7. Penicillin Oral Immunologic IgE Induction of Drug Tolerance (eg, Desensitization) Protocol
Stepa 1 2 3 4 5 6 7 8 9
10 11 12 13 14
Penicillin, mg/mL
0.5 0.5 0.5 0.5 0.5 0.5 0.5 5 5 5
50 50 50 50
Amount, mL 0.1 0.2 0.4 0.8 1.6 3.2 6.4 1.2 2.4 5 1 2 4 8
Dose given, mg
0.05 0.1 0.2 0.4 0.8 1.6 3.2 6
12 25 50
100 200 400
Observe patient for 30 minutes, then give full therapeutic dose. a Interval between doses is 15 minutes.
Table 8. Rapid Aspirin Challenge/Desensitization Protocol for Patients With Coronary Artery Disease Requiring Aspirin Timea 0
15 30 45 60 75 90
105 120 135
Aspirin dose, mg 0.1 0.3 1 3
10 20 40 81
162 325
a Dosing interval shown is 15 minutes, but may also dose every 20 minutes with premedication with oral antihistamine.
Cumulative dose, mg
0.05 0.15 0.35 0.75 1.55 3.15 6.35
12.35 24.35 49.35 100 200 400 800
22
