Pediatric Dose
(Adult/Child) Class
15 mg/kg/dose IV q6h B-II/A-II B-II/C-III
6-10 mg/kg/dose IV daily
10 mg/kg/dose PO/IV q8h Max: 600 mg/dose
10-13 mg/kg/dose PO/IV q6-8h Max: 40 mg/kg/day
No data B-II/C-III B-III/A-II
B-III/ND A-II
Comments
A-II
Long-term oral suppressive antibiotics (eg, TMP-SMX, a tetracycline, a fluoroquinolone,¶ or clindamycin) with or without rifampin may be considered in selected cases, particularly if device removal is not possible (B-III).
A-II
For details please see antibiotic recommendations for device-related osteoarticular infections in full text guidelines at: http://www.idsociety.org/content. aspx?id=4432#mrsa
A-II ¶
Due to the potential emergence of fluoroquinolone resistance, particularly if adequate surgical debridement is not possible, it should be given in conjunction with rifampin.
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