Comments Pediatric Dose 10-13 mg/kg/dose PO
q6-8h Max: 40 mg/kg/day
Trimethoprim 4-6 mg/kg/dose, sulfamethoxazole 20-30 mg/kg/dose PO q12h
< 45 kg: 2 mg/kg/dose PO q12h > 45 kg: adult dose
4 mg/kg PO/IV x 1, then 2 mg/kg/dose PO/IV q12h
10 mg/kg/dose PO q8h Max: 600 mg/dose
(Adult/Child) Class A-II A-II
Clostridium difficile-associated disease may occur more frequently compared to other oral agents.
TMP-SMX‡
not recommended for women in the third trimester of pregnancy and for children less than 2 months.
A-II A-II
Tetracyclines are not recommended for children under 8 years old (A-II) and are pregnancy category D.
A-II Please refer to Red Book A-II
More expensive compared to other alternatives.
For non-purulent cellulitis, empiric therapy for β-hemolytic streptococci is recommended (A-II). The role of CA-MRSA is unknown. Empiric coverage for CA-MRSA is recommended in patients who fail to respond to β-lactam therapy and may be considered in those with systemic toxicity.
Please refer to Red Book See above for TMP- SMX‡ dosing
and tetracycline
10 mg/kg/dose PO q8h Max: 600 mg/dose
10-13 mg/kg/dose PO
q6-8h Max: 40 mg/kg/day
A-II A-II
Provide coverage for both β-hemolytic streptococci and CA-MRSA.
A-II is pregnancy category C/D and
* Cultures from abscesses and other purulent SSTI are recommended in patients treated with anti- biotic therapy, those with severe local infection or signs of systemic illness, patients who have not responded adequately to initial treatment, and if there is concern for a cluster or outbreak (A-III).
† Based on the extent of disease and the patient's clinical response. ‡ Adjust dose for renal impairment – see Prescribing Information for renal dosing. 3
