Selecting a Treatment Regimen Antiplatelet and Anticoagulant Therapy Options
Class/Agent (Brand)
Anti-platelet Aspirin
Clopidogrel† (Plavix®
)
Prasugrel‡ (Effient®
)
Ticlodipine (Ticlid®
) VKAs
Warfarin (Coumadin® Jantoven®
) *See Prescribing Information for details.
†FDA warning: Clopidogrel (Plavix) can be less effective in poor metabolizers. ‡Indicated for ACS undergoing PCI. Not recommended in patients with prior TIA or stroke, age greater than 75 years or in those in whom CABG is planned.
§Thrombotic stroke. AE, arterial emboli; AF, atrial fibrillation; CAD, coronary artery disease; PE, pulmonary embolism; PV, prosthetic valve; VT, venous thrombosis
, PO Adjust to INR FDA Approved Indications* Route Dose
PO 75-325 mg qd PO 75-600 mg qd
PO Init: 60 mg then 10 mg qd with aspirin
PO 250 mg bid § VT PE CAD AF PV AE
