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Coronary Artery Disease At risk Symptomatic CAD
High risk
≥ 10% 10-year risk
Women
monitoring is difficult
If VKA
< 65
≥ 65
Grade 2A
Grade 2B
Grade 2B
AND
(target INR 1.5) if monitoring is easy (2A)
Low-dose VKAs
75-100 mg qd Aspirin
Clopidogrel† 75 mg qd
aspirin intolerance (1B)
Clopidogrel† for †FDA warning: Clopidogrel (Plavix) can be less effective in poor metabolizers.
