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Diagnosis of TB Guidelines PDF

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4 Diagnosis Figure 1. Paradigm for Evaluation of Those with LTBI Based on Risk of Infection, Risk of Progression to Tuberculosis, and Benefit of Therapy Risk of Infection Groups with Increased Likelihood of Infection with Mtb Benefit of Therapy Household contact or recent exposure of an active case Yes Mycobacteriolog y laboratory personnel Not demonstrated Immigrants from high burden countries (>20/100,000) Not demonstrated Residents and employees of high risk congregate settings Yes None Not demonstrated In developing a diagnostic approach for the evaluation of those with suspected LTBI, the panel recommends the clinician weigh the likelihood of infection, the likelihood of progression to tuberculosis if infected, and the benefit of therapy (Horsburgh and Rubin, Clinical practice: latent tuberculosis infection in the United States. N Engl J Med. 2011; 364:1441–8). Recommendations were formulated for each of the 3 groups illustrated above. ese groups are concordant with current recommendations for the interpretation of the tuberculin skin test (American oracic Society, Targeted tuberculin testing and treatment of latent tuberculosis infection. MMWR Recomm Rep. 2000; 49:1–51).

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