13
Linezolid
Age <12 years: 30 mg/kg (8)
c
Age ≥12 years: 20 mg/kg (12)
c
1200 mg (12)
Liposomal amphotericin B 3–5 mg/kg (24)
3-5 mg/kg (24)
d
Meropenem 120 mg/kg (8) 6 g (8)
Moxifloxacin
e
Dose not established 400 mg (24)
Nafcillin 200 mg/kg (6) 12 g (4)
Oxacillin 200 mg/kg (6) 12 g (4)
Penicillin G 300,000 units/kg (4–6) 24 million units (4)
Posaconazole –
800 mg (6–12)
f
Rifampin
20 mg/kg (24)
g
600 mg (24)
Tobramycin
a
7.5 mg/kg (8) 5 mg/kg (8)
Trimethoprim-
sulfamethoxazole
h
10–20 mg/kg (6–12) 10-20 mg/kg (6–12)
Vancomycin
i
60 mg/kg (6) 30-60 mg/kg (8–12)
Voriconazole
16 mg/kg (12)
j,k,l
8 mg/kg (12)
j,k
a
Need to monitor peak and trough serum concentrations.
b
Not approved in pediatrics; dose based on trials registered with clinical trials.gov (NTC01522105)
and (NTC01728376).
2–6 years: 12 mg/kg (24)
7–11 years: 9 mg/kg (24)
12–17 years: 7 mg/kg (24)
c
Not to exceed the adult dose.
d
Dose of 5–7.5 mg/kg every 24 hours in patients with Aspergillus infection.
e
No data on optimal dose in patients with bacterial meningitis.
f
Dose of 200 mg orally every 6 hours initially, then 400 mg orally every 12 hours. e newer
formulations (ie, intravenous and extended-release tablets) of posaconazole appear to have
improved pharmacokinetic properties, but there are no available data on their use in treatment of
fungal infections of the central nervous system.
g
Maximum dosage of 600 mg.
h
Dosage based on trimethoprim component.
i
Maintain serum trough concentrations of 15–20 μg/mL in adult patients who receive intermittent
bolus administration. Some clinicians administer vancomycin with a loading dose of 15 mg/kg,
followed by a continuous infusion of 60 mg/kg/day.
j
Load with 6 mg/kg intravenous every 12 hours for 2 doses in adults and 9 mg/kg every 12 hours for
2 doses in children aged 2–12 years.
k
Maintain serum trough concentrations of 2–5 μg/mL.
l
Maximum maintenance dose in children of 350 mg every 12 hours.
Table 2. Recommended Dosages of Antimicrobial Agents in
Infants and Children, and Adults with Normal Renal
and Hepatic Function (cont'd)
