Key Points
Antihyperglycemic Therapy Glycemic Targets
ÎHbA1c < 7.0% (mean plasma glucose ~150-160 mg/dL [~8.3-8.9 mmol/L])
ÎFasting and premeal glucose < 130 mg/dL (< 7.2 mmol/L) ÎPostprandial glucose < 180 mg/dL (< 10.0 mmol/L)
ÎIndividualization is key: • More stringent targets (HbA1c 6.0-6.5%) – patients with short disease duration, long life expectancy, no significant cardiovascular disease
• Less stringent targets (HbA1c 7.5-8.0%+) – patients with history of severe hypoglycemia, limited life expectancy, advanced complications, extensive comorbid conditions
ÎAvoidance of hypoglycemia Figure 4. Approach to Management of Hyperglycemia
Reprinted with permission from: Inzucchi SE, et al. Diabetes Care. 2012 Jun;35(6):1364-1379. 2
