Advantages
• No hypoglycemia • ? ↓ CVD events (Cycloset Safety Trial)
• No hypoglycemia • Weight reduction • ? Potential for improved β-cell mass/function
• ? Cardiovascular protective actions
Disadvantages
• Generally modest HbA1c efficacy • Dizziness/syncope • Nausea • Fatigue • Rhinitis
• Gastrointestinal side effects (nausea/ vomiting)
• Injectable • Training requirements
• ? Acute pancreatitis • C-cell hyperplasia/medullary thyroid tumors in animals
Cost High
High
• ↓ Postprandial glucose excursions
• Weight reduction
• Generally modest HbA1c efficacy • Gastrointestinal side effects (nausea/ vomiting)
• Hypoglycemia unless insulin dose is simultaneously reduced
• Injectable • Frequent dosing schedule
• Universally effective • Theoretically unlimited efficacy
• ↓ Microvascular risk (UKPDS)
• Hypoglycemia • Weight gain • ? Mitogenic effects • Injectable • Training requirements • "Stigma" (for patients)
Variablee
High
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