Treatment
Do antihistamines
help with GI
symptoms
attributable to SLIT?
ere is no known benefit of antihistamines for reducing the GI
symptoms that develop with SLIT.
Can antihistamines
be taken before SLIT
administration? Will
this help with oral
symptoms of SLIT?
Use of antihistamines does not need to be stopped and may reduce
local oral symptoms. On the other hand, intermittent use of
antihistamines potentially increases the risk of adverse reactions in
SCIT.
Concurrent GI
infection and the
administration of
SLIT
Although there are limited published data on risks associated with
GI infections, for moderate to severe GI infections we recommend
that SLIT be discontinued until improvement occurs.
Risk with a history
of food-induced
anaphylaxis
To date there has not been any reported increased risk of
administering SLIT to patients who report systemic reactions to
foods. Although the product information indicates that there is a
contraindication for any systemic allergic reaction (which could
include food-induced anaphylaxis), there are no data indicating
that these patients should be excluded from treatment using
inhalant SLIT tablets.
Risk with a history of
oral allerg y syndrome
Although data are limited, the benefit of SLIT seems to outweigh
any potential risk when treating patients with the oral allerg y
syndrome.
Aer a recent
moderate to severe
allergic reaction to a
food or medication
Hold SLIT and contact the allergist within 72 hours of the reaction
for further instruction.
a
is is based solely on expert opinion since there is no published evidence to offer guidance.
Table 3. Suggested Guidelines for the Practicing Allergist
Regarding the Use of FDA-Approved SLIT Products
(cont'd)
Question or
concern Expert suggestion and rationale
