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Table 7. Lymphocyte Phenotype Classification of SCID
Disease Genes
T
–
B
–
NK
–
Adenosine deaminase ADA
Adenylate kinase (reticular dysgenesis) AK2
T
–
B
–
NK
+
Artemis DCLRE1C
Cernunnos NHEJ1
DNA-dependent protein kinase PRKDC
DNA ligase IV LIG4
RAG1 and RAG2 RAG1, RAG2
T
–
B
+
NK
–
X-linked SCID IL2RG
JAK3 deficiency JAK3
CD25 deficiency IL2RA
T
–
B
+
NK
+
CD3 complex defects CD3D, CD3E, CD3Z
Coronin 1A deficiency CORO1A
CD45 deficiency PTPRC
IL-7 receptor deficiency IL7RA
Combined B- and T-Cell Immunodeficiencies
