16
Treatment
Table 5. Regimens for Prophylaxis of Bacterial Respiratory
Tract Infections
Antibiotic Regimen for children Regimen for adults
Oral agents
a
Amoxicillin (consider with
clavulanate, if necessary)
10-20 mg/kg daily or twice
daily
500-1,000 mg daily or
twice daily
Trimethoprim (TMP)/
sulfamethoxazole dosing
for TMP)
5 mg/kg daily or twice daily 160 mg daily or twice daily
Azithromycin 10 mg/kg weekly or 5 mg/kg
every other day
500 mg weekly or 250 mg
every other day
Clarithromycin 7.5 mg/kg daily or twice
daily
500 mg daily or twice daily
Doxycycline Age >8 y: 25-50 mg daily or
twice daily
100 mg daily or twice daily
Inhaled agents
Gentamicin Age >6 y: 80 mg twice daily, 28 days on, 28 days off, OR
21 days on, 7 days off
Tobramycin Age >6 y: 300 mg twice daily, 28 days on, 28 days off
a
ese are commonly used regimens. If these agents are not effective or are not tolerated, other
drugs can be considered, including cefuroxime, cefprozil, cefpodoxime, ciprofloxacin or other
quinolone, or others, depending on the individual circumstances of the patient.
Autoinflammatory
disorders
No No No • Cytokine (IL-1, TNF, IL-6)
inhibitors: CAPS, DIRA,
PAPA, PSMB8, TRAPS
• Steroids: Blau syndrome,
DITRA, HIDS, TRAPS
• Retinoids: DITRA
• Colchicine: TRAPS
Complement
deficiency
No No No • Antibiotics: all
• Pneumococcal vaccine: C1, C2,
C3, C4
• Meningococcal vaccine: C5-C9
• Immunomodulators: C1, C2,
C4, factors H and I
Cytokine
autoantibody-
mediated disorders
Possible No No • Plasmapheresis
• Rituximab
• Cytokine supplement
a
Yes or No indicates whether or not IgG replacement is a component of standard therapy for this disorder.
Table 4. Summary of Therapeutic Considerations
for Primary Immunodeficiencies and Their
Complications (cont'd)
Diagnosis IgG
a
HSCT
Gene
therapy
