ASCO GUIDELINES Bundle

Invasive Cervical Cancer

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10 Treatment IB2 and IIA2 If chemotherapy is available, use NACT followed by extrafascial hysterectomy; if chemotherapy is not available, extrafascial hysterectomy (modification as deemed necessary) may be performed if the surgical capacity is present (CB, L, W) If chemotherapy is available, NACT followed by radical hysterectomy (see Note) plus PLND ± para-aortic LN sampling may be an option d,f (EB, I, M) If EBRT is available, but not brachytherapy, then chemoRT followed by extrafascial hysterectomy or RT (if chemotherapy not available) followed by extrafascial hysterectomy (see Note) (CB, L, W) OR if no EBRT is available, then brachytherapy and concurrent low-dose platinum- based chemotherapy followed by radical hysterectomy (see Note) f When brachytherapy is not available, extrafascial or radical hysterectomy is recommended only when there is persistent central pelvic disease and selective lymphadenectomy or LN biopsy for suspicious lesions (EB/CB, L-I, W-M) Radical hysterectomy plus PLND ± para-aortic LN sampling (EB, L, W) Table 3. Recommendations for Stage IA, IB, and IIA Disease (cont'd) Type of Disease Basic Limited

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