Duodenum
In patients undergoing EGD for
dyspepsia as the sole indication, and
in the absence of signs or symptoms
associated with an increased risk
of celiac disease, the AGA suggests
NOT obtaining routine biopsies of
the normal-appearing duodenum to
detect celiac disease.
Conditional Very low
In immunocompromised patients
undergoing EGD for dyspepsia as the
sole indication, the AGA suggests
obtaining routine biopsies of the
normal-appearing duodenum for the
detection of GVHD in post-allogeneic
tissue transplantation patients and for
opportunistic infections.
Conditional Very low
When biopsies are obtained from
the normal-appearing duodenum,
the AGA suggests NOT performing
routine special staining of the
specimens.
Conditional Very low
Summary of Recommendations of the AGA Guideline on
Upper-GI Biopsies to Evaluate Adult Dyspepsia (cont'd)
Anatomic
location Statement
Strength of
recommendation
Quality of
evidence
Locations of Gastric Biopsy Recommended by the Updated
Sydney System
(A) Lesser curvature of the antrum; (B) greater curvature of the antrum; (C) lesser
curvature of the body; (D) greater curvature of the body; and (E) incisura angularis.
Adapted with permission from Dixon et al. Am J Surg Pathol. 1996;20:1161–1181.
