Figure 2
Assess Comorbidities and Disease-
and Therapy-Related Complications
Patient Engagement
and Coping
Infection
Aspirin or NSAIDs
Non-Compliance
Adverse Reaction to
Medical Therapy
Thromboembolic
Complications
Colorectal Cancer/
Dysplasia
a
Toxic Megacolon/
Fulminant Colitis
Assess Patient Preferences, Belief Systems,
Disease Knowledge, Depression,
Psychosocial Support
Treat Infection
(C. difficile, Other Bacteria, CMV, Parasites)
Stop Aspirin or NSAIDs
Educate and Support Patient
Modify Therapy
Treat DVT/PE
Colectomy
Consult Surgery
a
Colectomy is recommended for: 1) endoscopically unresectable polypoid high-grade or low-
grade dysplasia, 2) invisible high-grade dysplasia on random biopsies, and 3) invisible low-grade
dysplasia on random biopsies if the dysplasia is found (a) at more than one site (multifocal
dysplasia), (b) on more than one occasion (repetitive dysplasia), and/or (c) at the time of initial
screening colonoscopy (prevalent dysplasia).
2
Colitis
