33
Mitigation and
Management
Approaches
d,f
Pregnant
Patients
f,g
Breastfeeding
Patients
f,h
Comments
Examples:
premedication;
saline loading ; test
dose; slow infusions
(~2–6 h); electrolyte
supplementation,
increased intervals
between doses, and/
or drug holidays, if
indicated. Avoid/
minimize use of other
nephrotoxic agents
(eg, nonsteroidal anti-
inflammatory drugs).
FDA pregnancy
category B
j
Probably
compatible (see
Recs. 78-79);
interruption of
breastfeeding may
be prudent.
See above (eg,
minimize use of
other nephrotoxic
agents) but modify
as appropriate
(eg, liposomal
amphotericin B
typically is infused
over ~2 h; minimum
of ~1 h).
FDA pregnancy
category B
j
(see
Recs. 78-79)
