21
Table 8. Clinically Significant Drug–Drug Interactions
Involving the Rifamycins
a
(cont'd)
Table 9. Suggested Pyrazinamide Doses, Using Whole
Tablets, for Adults Weighing 40–90 kg
a
Regimen
Weight, kg
b,c
40–55 56–75 76–90
Daily
(mg/kg )
1000 mg (18.2–25.0) 1500 mg (20.0–26.8) 2000 mg (22.2–26.3)
rice weekly
(mg/kg )
1500 mg (27.3–37.5) 2500 mg (33.3–44.6) 3000 mg (33.3–39.5)
Twice weekly
(mg/kg )
2000 mg (36.4–50.0) 3000 mg (40.0–53.6) 4000 mg (44.4–52.6)
a
With normal renal function.
b
Based on estimated lean body weight. Optimal doses for obese patients are not established.
c
Numbers in parentheses are the calculated mg/kg doses for patients at the highest and lowest body
weights in the weight band.
Psychotropic
drugs
Nortriptyline TDM recommended; may require
dose increase or change to alternate
psychotropic drug.
Haloperidol, quetiapine Monitor clinically; may require a
dose increase or use of an alternate
psychotropic drug.
Benzodiazepines (eg,
diazepam, triazolam),
zolpidem, buspirone)
Monitor clinically; may require a
dose increase or use of an alternate
psychotropic drug.
a
See the following useful websites for updated information regarding drug interactions:
AIDSinfo [http://aidsinfo.nih.gov/contentfiles/lvguidelines/adult_oi.pdf ],
Centers for Disease Control and Prevention [http://www.cdc.gov/tb/publications/guidelines/
TB_HIV_Drugs/default.htm],
University of California San Francisco [http://hivinsite.ucsf.edu/insite?page=ar-00-02],
University of Liverpool [http://www.hiv-druginteractions.org/],
Indiana University [http://medicine.iupui.edu/clinpharm/ddis/], and
University of Maryland [http://umm.edu/health/medical/drug-interaction-tool].
