17
Table 6. Other Causes of Abnormal Liver Function Tests
That Should Be Excluded
• Viral hepatitis (hepatitis A, B, and C in all patients; Epstein-Barr virus,
cytomegalovirus, and herpes simplex in immunosuppressed patients)
• Biliary tract disease
• Alcohol
• Other hepatotoxic drugs (eg, acetaminophen, acetaminophen-containing multi-agent
preparations, lipid-lowering agents, other drugs)
• Select herbal and dietary supplements
Table 7. Conditions or Situations in Which Therapeutic Drug
Monitoring May Be Helpful
• Poor response to tuberculosis treatment despite adherence and fully drug-susceptible
Mycobacterium tuberculosis strain
• Severe gastrointestinal abnormalities: severe gastroparesis, short bowel syndrome,
chronic diarrhea with malabsorption
• Drug–drug interactions
• Impaired renal clearance: renal insufficiency, peritoneal dialysis, critically ill patients
on continuous renal replacement
• HIV infection
• Diabetes mellitus
• Treatment using second-line drugs
