Weight-Based Chemotherapy

ASCO Weight-Based Chemotherapy

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Calculation Tools for BSA and BMI Calculation Toolsa Carboplatin Calculation Resource Formula Name Formula Calvert Calculation Toolb Total Dose (mg) = (target AUC) × (GFR + 25) Carboplatin Dose Calculator Scan to use the online https://hccapps.musc.edu/hemonc/ carboplatin_dose_calculator.htm BSA Calculation Resources Formula Name Formula Calculation Tool Chemotherapy is usually dosed by square meter of body surface area (BSA). BSA has been chosen rather than body weight as the basis for calculation for two reasons. First, BSA has been demonstrated to provide a more accurate comparison of activity and toxicity for certain drugs. Second, BSA can be more closely correlated with cardiac output, which determines the blood flow to the liver and kidneys, thus influencing drug elimination. Boyd DuBois and DuBois Gehan and George Haycock, et al. Mosteller (Adults and Children) a BSA(m2 0.0003207 × Ht(cm)0.3 ) = Ht(cm)0.725 BSA(m2 weight(g)(0.7285 – (0.0188 × LOG10weight(g))) BSA(m2 ) = Wt(kg)0.425 × 0.007184 Ht(cm)0.42246 BSA(m2 Ht(cm)0.3964 BSA (m2 ) = BSA (m2 ) = × × ) = Wt(kg)0.51456 × 0.0235 ) = Wt(kg)0.5378 × 0.024265 This practice tool for physicians is a dosing table derived from an ASCO® practice guideline. The practice guideline and this table are not intended to substitute for the independent professional judgment of the treating physician. Practice guidelines do not account for individual variation among patients and may not reflect the most recent evidence. This table does not recommend any particular product or course of medical treatment. Use of the practice guideline and this table is voluntary. The full practice guideline and additional information are available at http://www.asco.org/guidelines/wbd. √ √ × × Ht(in) × Wt(lb) 3131 Ht(cm) × Wt(kg) 3600 http://www.medcalc.com/body.html Scan to use the online MedCalc calculator

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