Contraindications
▶ Active liver disease ▶ Arterial bleeding ▶ Pregnant or nursing women or those desiring to be pregnant
▶ Active liver disease ▶ Arterial bleeding ▶ Pregnant or nursing women or those desiring to be pregnant
▶ Active liver disease ▶ Pregnant or nursing women or those desiring to be pregnant
▶ 80 mg dose of simvastatin is only for previous users
Clinical Trial Results None completed
None completed
Reduced major atherosclerotic events (non-fatal myocardial infarction or coronary death, non-hemorrhagic stroke, or any arterial revascularization procedure) in patients with chronic kidney disease.
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Ballantyne CM, Davidson MH, McKenney J, et al. Comparison of the efficacy and safety of a combination tablet of niacin extended-release and simvastatin with simvastatin 80 mg monotherapy: the SEACOAST II (high-dose) study. J Clin Lipidol. 2008;2:79-90. Vytorin®
Catapano AL, Davidson MH, Ballantyne CM, et al. Lipid-altering efficacy of the ezetimibe/simvastatin single tablet versus rosuvastatin in hypercholesterolemic patients. Curr Med Res Opin. 2006;22(10):2041-2053.
Prescribing Information, Merck/Schering-Plough Pharmaceuticals, North Wales, PA.
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