Contraindications
Relative (statin specific: see individual PI): ▶ Concomitant use of certain drugs (cyclosporine, macrolide antibiotics, various antifungal agents and cytochrome P-450 inhibitors [fibrates and niacin should be used with appropriate caution])
Absolute: ▶ Dysbetalipoproteinemia ▶ TG > 400 mg/dL Relative: ▶ TG > 200 mg/dL
Absolute: ▶ Unexplained hepatic dysfunction, active peptic ulcer, arterial bleeding
Relative: ▶ DM ▶ Hyperuricemia ▶ Peptic ulcer disease
Absolute: ▶ Severe renal dysfunction or dialysis ▶ Active liver disease & unexplained aminase elevation
▶ Gall bladder disease ▶ Nursing mothers
Reduced major coronary events
Absolute: ▶ Active or chronic liver disease ▶ Pregnancy, lactation or desire to become pregnant
Clinical Trial Results
Reduced major coronary events, CHD deaths, need for coronary procedures, stroke, and total mortality
Reduced major coronary events and CHD deaths
Reduced major coronary events and possibly total mortality
▶ Previous sensitivity
No outcome trials completed
Reduced mortality and sudden death in patients with history of MI, as well as patients with CHF
Relative: ▶ Fish hypersensitivity
Improved mortality and reduced sudden death in MI patients and those with CHF
15
