Table 2. Initial Intravenous Adult and Child Doses of Antibiotics
for Empiric Treatment of Complicated Intra-Abdominal Infections
Antibiotic (Brand)
Ticarcillin/clavulanic acid (Timentin®
) Adult Dosagea β-lactam/β-lactamase inhibitor combinations
Ampicillin sodium Piperacillin/tazobactam
Carbapenems Ertapenem (Invanz®
Imipenem-cilastatin
Cephalosporins Cefazolin (Kefzol®
Cefepime (Maxipime® Cefotaxime (Claforan® Cefoxitin (Mefoxin® Ceſtazidime (Fortaz® Ceſtriaxone (Rocephin® Cefuroxime (Zinacef ®
Fluoroquinolones Ciprofloxacin (Cipro®
, generic)
, generic) , generic)
, generic) , generic)
, generic) , generic)
Levofloxacin (Levaquin® Moxifloxacin (Avelox®
)
Others Metronidazole (Flagyl®
Clindamycin Tigecycline (Tygacil® ) Gentamicin, tobramycin (generic)
100 mg initial dose; 50 mg every 12 h
5-7 mg/kgd every 24 he 3-7.5 mg/kg/day every 8-24 h
a Dosages are based on normal renal and hepatic function. b Dose in mg/kg should be based on total body weight. c β-lactam antibiotic dosages should be maximized if undrained intra-abdominal abscesses may be present. d Initial dosing regimens for aminoglycosides should be based on adjusted body weight. e Serum drug concentration monitoring should be considered for dosage individualization.
, generic) )
, generic) 1-2 g every 8 h
1-2 g every 6-8 h 2 g every 6 h
1-2 g every 12-24 h 1.5 g every 8 h
400 mg every 12 h 750 mg every 24 h 400 mg every 24 h
500 mg every 8-12 h or 1500 mg every 24 h
30-40 mg/kg/day every 8 h 20-40 mg/kg/day every 6-8 h )
3.1 g every 6 h (FDA labeling is 200 mg/kg/day in divided doses every 6 hours for moderate infections and 300 mg/kg/day in divided doses every 4 hours for severe infections)
200-300 mg/kg/day of ticarcillin component every 4-6 hc
Child Dosagea,b
200 mg/kg/day every 6 hd 200-300 mg/kg/day of piperacillin component every 6-8 hd
1 g every 24 h
3 mos-12 years: 15 mg/kg twice daily (not to exceed 1 g/day) every 12 h 60-100 mg/kg/day every 6 hc
100 mg/kg/day every 12 hc 150-200 mg/kg/day every 6-8 hc
150 mg/kg/day every 8 hc 50-75 mg/kg/day every 12-24 hc 150 mg/kg/day every 6-8 hc
