r's Disease Side Effects
Nausea, vomiting, and diarrhea (sometimes can be reduced when taken with food, reducing dose, slower titration, or dividing the dose to bid) Muscle cramps Urinary incontinence Syncope Bradycardia (doses >10 mg/day) Fatigue
Same as for donepezil Comments and Cautions
5 mg dose is effective Caution when using in people with cardiac conduction conditions such as symptomatic bradycardia, or with a history of falls or syncope (may want to avoid or seek cardiac consult)
Starting dose is not therapeutic. Maximum dose 16 mg per day if renal impairment Other cautions same as donepezil
Nausea, vomiting, and diarrhea (must be taken with food) More nausea and vomiting than with other ChEIs Anorexia Maybe less muscle cramping than with other ChEIs Bradycardia (rare at therapeutic doses) Other side effects the same as other ChEIs
Nausea, vomiting, at 4.6 mg/24 hr patch same as with placebo Other side effects the same as donepezil and galantamine
Starting dose is therapeutic. Cautions same as for donepezil and galantamine
Starting dose is not therapeutic. Cautions same as for donepezil and galantamine
Headache Dizziness Sedation Agitation Constipation
Target dose of 5 mg bid is recommended in patients with severe renal impairment (ClCr of 5-29 mL/min based on the Cockroſt- Gault equation) Note: Merz (Germany) recommends that for patients with moderate renal impairment (ClCr 40-60 ml/min/1.73 m2), daily dose should be reduced to 10 mg/d. No data are available for patients with severely reduced kidney function.
