Class/Agent (Brand)
Oral Antiplatelet Aspirin
Clopidogrel (Plavix®
) VKA
Warfarin (Coumadin® Jantoven®
) ,
Injectable Anticoagulant Heparin (UFH) LMWH
Enoxaparin (Lovenox®
) PO Adjust to INR
Table 1. Anticoagulants Route
PO PO
Dosea
Comments
50-100 mg once daily 75 mg once daily
IV
Subcut, (IV)
Adjust to APTT
Preventive: 30-40 mg daily Rx: 1 mg/kg q12h or
1.5 mg daily
Dalteparin (Fragmin®
)
Subcut Preventive: 2,500-5,000 units daily Rx:
FDA-approved for prophylaxis and treatment of DVT, prophylaxis of ischemic complications of unstable angina and non–Q-wave MI, and treatment of acute STEMI
200 units/kg daily
Tinzaparin (Innohep®
) Subcut 175 units/kg daily
FDA-approved for prophylaxis of DVT, prophylaxis of ischemic complications of unstable angina and non–Q-wave myocardial infarction, and extended treatment of symptomatic venous thromboembolism in patients with cancer
FDA-approved for the treatment of acute symptomatic DVT with or without pulmonary embolism when administered in conjunction with warfarin sodium
Recombinant tissue plasminogen activator (r-tPA) IV
Reteplase (Retavase®
)
Tenecteplase (TNKase®
) IV a See PI for full prescribing information.
30-50 mg (weight-based)
10 units twice 30 minutes apart
Indicated for use in the management of acute myocardial infarction
Indicated for use in the reduction of mortality associated with acute myocardial infarction
