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2 Key Points Î Thyrotoxicosis is a condition having multiple etiologies, manifestations, and potential therapies. Î The term ''thyrotoxicosis'' refers to a clinical state that results from inappropriately high thyroid hormone action in tissues due to inappropriately high tissue thyroid hormone levels. Î The term ''hyperthyroidism,'' as used in these guidelines, is a form of thyrotoxicosis due to inappropriately high synthesis and secretion of thyroid hormone(s) by the thyroid. Î Appropriate treatment of thyrotoxicosis requires an accurate diagnosis. • For example, thyroidectomy is an appropriate treatment for some forms of thyrotoxicosis and not for others. Î Additionally, β-blockers may be used in almost all forms of thyrotoxicosis, whereas antithyroid drugs (ATDs) are useful in only some. Î In the United States, the prevalence of hyperthyroidism is approximately 1.2% (0.5% overt and 0.7% subclinical). Î The most common causes include Graves' disease (GD), toxic multinodular goiter (TMNG), toxic adenoma (TA) and and painless thyroiditis. Guideline Grading System Strength of Recommendation Quality of Evidence SR Strong Recommendation H High-quality evidence WR Weak Recommendation M Moderate-quality evidence NR No Recommendation L Low-quality evidence In Insufficient

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