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AAO Primary Open Angle Glaucoma Suspect

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Management Table 2. Glaucoma Medications Drug Classification Methods of Action Potential Side Effects Prostaglandin analogs Increase uveoscleral and/or trabecular outflow • Increased and misdirected eyelash growth • Periocular hyperpigmentation • Conjunctival injection • Allergic conjunctivitis/contact dermatitis • Keratitis • Possible herpes virus activation • Increased iris pigmentation • Uveitis • Cystoid macular edema • Periorbitopathy • Migraine-like headache • Flu-like symptoms Beta-adrenergic antagonists (beta-blockers) Decrease aqueous production • Allergic conjunctivitis/contact dermatitis • Keratitis • Bronchospasm (seen with nonselective) • Bradycardia • Hypotension • CHF (classic teaching, although cardiologists use beta-blockers as first line treatment in CHF) • Reduced exercise tolerance • Depression • Impotence Alpha-adrenergic agonists Nonselective: improve aqueous outflow Selective: decrease aqueous production; decrease episcleral venous pressure or increase uveoscleral outflow • Allergic conjunctivitis/contact dermatitis • Follicular conjunctivitis • Dry mouth and nose • Hypotension • Headache • Fatigue • Somnolence 6

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