• The need to regularly assess the fundus
• Neovascular, uveitic, or malignant glaucoma
20%–25% C
• Sulfonamide allerg y
• Kidney stones
• Aplastic anemia
• Thrombocytopenia
• Sickle cell disease
15%–20% C
• Sulfonamide allerg y
• Kidney stones
• Aplastic anemia
• Thrombocytopenia
• Sickle cell disease
20%–30% C
• Renal failure
• CHF
No data C
a
Data from the Heijl A, Traverso CE, eds. Terminolog y and Guidelines for Glaucoma. European
Glaucoma Society. 4th ed. Savona, Italy: PubliComm; 2014:146–51. Available at: www.eugs.org/
eng/EGS guidelines4.asp. Accessed May 29, 2015.
b
FDA Pregnancy Category B = Animal reproduction studies have failed to demonstrate a risk to the
fetus and there are no adequate and well-controlled studies on pregnant women.
FDA Pregnancy Category C = Animal reproduction studies have shown an adverse effect on the
fetus and there are no adequate and well-controlled studies in humans, but potential benefits may
warrant use of the drug in pregnant women despite potential risks.
Potential Contraindications IOP Reduction
a
FDA Pregnancy
Safety Category
b
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