Treatment
Table 4. Antimicrobial Regimens for ABRS in Adults Indication
First Line (Daily Dose)
Initial empirical therapy Amoxicillin-clavulanate (500 mg/125 mg PO tid, or 875 mg /125 mg PO bid)
β-lactam allergy
Risk for antibiotic resistance or
Second Line (Daily Dose)
> Amoxicillin-clavulanate (2000 mg/125 mg PO bid)
> Doxycycline (100 mg PO bid or 200 mg PO daily)
> Doxycycline (100 mg PO bid or 200 mg PO daily)
> Amoxicillin-clavulanate (2000 mg/125 mg PO bid)
Failed initial therapy
Severe infection requiring hospitalization
> Ampicillin/sulbactam (1.5 g-3 g IV q6h)
> Levofloxacin (500 mg PO daily) > Moxifloxacin (400 mg PO daily)
> Levofloxacin (500 mg PO daily) > Moxifloxacin (400 mg PO daily)
> Levofloxacin (500 mg PO or IV daily)
> Moxifloxacin (400 mg PO or IV daily)
> Ceftriaxone (1-2 g IV q24h) > Cefotaxime (2 g IV q4-6 h)
