Comments Administer with or without food.
Replacing rosiglitazone and metformin taken separately as combination therapy, or if uncontrolled on rosiglitazone or metformin alone. Administer in divided doses with meals to reduce GI side effects associated with metformin.
Replacing rosiglitazone and SU taken separately as combination therapy, or if uncontrolled on rosiglitazone or SU alone. Administer with first meal of the day.
Table 13. Summary of Insulin Regimens
Insulin Regimen
Basal Premixed
Prandial/ mealtime
Basal-bolus (multiple daily injections)
Continuous subcutaneous insulin infusion
Components and Frequency of Administration Levemir®
Lantus®
(daily or twice a day) (once daily)
NovoLog®
(usually twice a day; occasionally used daily or 3 times a day) Apidra®
Apidra®
combination with detemir or glargine (daily) Apidra®
, NovoLog® , NovoLog®
, NovoLog®
Mix 70/30 or Humalog® , or Humalog® , or Humalog®
, or Humalog® Insulin Time-action Profiles Rapid (aspart, glulisine, lispro)
Short (Regular) Intermediate [NPH]
Basal (detemir or glargine) Mix 75/25™ (with meals) (with meals) in
Injections per Day
1 or 2 1
2 3 4
Continuous
Causes or exacerbates CHF in some patients. If signs and symptoms of CHF develop, treat accordingly and discontinue TZD. Contraindicated in NYHA Class III or IV CHF. Administration in patients receiving insulin or nitrates is not recommended.
0 2 4 6 8 10 12 14 16 Time (hours)
18 20 25
Relative Insulin Effect
