Comments Administer with meals; maximum effective dose is 2000 mg daily.
Increase dosage by 500 mg/d weekly; if glycemic control not improved, switch to twice daily regimen. May have better GI tolerance than immediate-release metformin.
Adjunct to diet and exercise. Consider lowering the dose of any concurrent insulin secretagogue.
Administer with or without food and after dialysis. Adjunct to diet and exercise. Limit dose to 2.5 mg daily if given concurrently with strong CYP3A4/5 inhibitors.
Swallow whole. Administer once daily with the evening meal. Limit ≤ 2.5 mg saxagliptin daily for patients also taking strong cytochrome P450 3A4/5 inhibitors (eg, ketoconazole).
Administer with or without food. Adjunct to diet and exercise; initial therapy in combination with metformin; add-on therapy to an SU when the single agent alone does not provide adequate glycemic control; add-on therapy to the combination of an SU and metformin when dual therapy does not provide adequate glycemic control.
Administer with meals; not recommended for patients with severe renal disease.
Not a substitute for insulin in insulin-requiring patients. Not recommended for use in patients with end-stage renal disease or severe renal impairment.
(ClCr < 30 mL/min/1.73 m2 )
Contraindicated if medullary thyroid carcinoma is present. Not a substitute for insulin in insulin-requiring patients. Use with caution in patients with renal or hepatic disease.
Administer with breakfast or first main meal.
Administer once daily dose 30 min before breakfast or first main meal. Dose > 15 mg/d should be divided and given twice daily. Administer with a meal.
Administer once daily dose with breakfast or first main meal. Dose > 10 mg/d should be divided and given twice daily.
Starting doses should not exceed daily doses of glyburide or metformin already being taken; dose increases can be made at 2-week intervals.
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