Selecting a Treatment Regimen
Table 5C. Characteristics of Protease Inhibitors (PIs) Drug
Formulation
Atazanavir (ATV) Reyataz®
Dosing Recommendations
100, 150, 200, 300 mg capsules ARV-naïve pts: 400 mg once daily or (ATV 300 mg + RTV 100 mg) once daily
With TDF or for ARV-experienced pts: (ATV 300 mg + RTV 100 mg) once daily
With EFV in treatment-naïve pts: (ATV 400 mg + RTV 100 mg) once daily
Darunavir (DRV) Prezista®
75, 150, 400, 600 mg tablets
ARV-naïve pts or ARV-experienced patients with no DRV mutations: (DRV 800 mg + RTV 100 mg) once daily
ARV-experienced pts with at least one DRV mutation: (DRV 600 mg + RTV 100 mg) bid
▶ Unboosted DRV is NOT recommended
▶ Take with food Fosamprenavir (FPV)
Lexiva® (a prodrug of amprenavir)
700 mg tablet or 50 mg/mL oral suspension
ARV-naïve pts: ▶ FPV 1,400 mg bid or ▶ (FPV 1,400 mg + RTV 100-200 mg) once daily or
▶ (FPV 700 mg + RTV 100 mg) bid
PI-experienced pts (once-daily dosing NOT recommended): ▶ (FPV 700 mg + RTV 100 mg) bid
With EFV: ▶ (FPV 700 mg + RTV 100 mg bid or ▶ (FPV 1,400 mg + RTV 300 mg) once daily (not FDA-approved)
▶ Take without regard to meals (if not boosted with RTV tablet)
Indinavir (IDV) Crixivan®
100, 200, 400 mg capsules
800 mg q8h Take 1 hr before or 2 hrs after meals; may take with skim milk or low-fat meal
With RTV: (IDV 800 mg + RTV 100-200 mg) bid (not FDA-approved)
▶ Take without regard to meals 14
▶ Suspension: Take without food ▶ FPV w/ RTV tablet: Take with meals
