Selecting a Treatment Regimen
Table 5C. Characteristics of Protease Inhibitors (PIs) Drug
Formulation
Tipranavir (TPV) Aptivus®
250 mg capsules or 100 mg/mL oral solution
Dosing Recommendations
(TPV 500 mg + RTV 200 mg) orally bid
▶ Unboosted TPV is NOT recommended
▶ TPV taken with RTV tablets: Take with meals
▶ TPV taken with RTV capsules or solution: Take without regard to meals
Table 5D. Characteristics of Integrase Strand Transfer Inhibitors (INSTI)
Drug
Raltegravir (RAL) Isentress®
Formulation 400 mg tablets Dosing Recommendations
Chewable tablets 100 mg scored and 25 mg
Adults: 400 mg bid Children and Adolescents: ≥ 12 years: 400 mg bid 6 - 11 years: ≥ 25 kg: one 400 mg bid or Chewable tablets: weight based– (see PI) Max: 300 mg bid
2 -<6 years: If ≥ 10 kg: Chewable tablets: weight based– Max: 300 mg bid
< 25 kg: Chewable tablets: weight based– Max: 300 mg bid
With rifampin: 800 mg bid ▶ Take without regard to meals
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