Elimination
▶ Renal excretion 70% ▶ Dosage adjustment in renal insufficiency recommended
Serum/Intracellular Half-lives
5-7 hrs/18-22 hrs
Adverse Events
▶ Minimal toxicity ▶ Severe acute exacerbation of hepatitis may occur in HBV- coinfected patients who discontinue 3TC
▶ Renal excretion 50% ▶ Dosage adjustment in renal insufficiency recommended
1.0 hr/7.5 hrs
▶ Peripheral neuropathy ▶ Lipoatrophy ▶ Pancreatitis ▶ Lactic acidosis with hepatic steatosis (rare but potentially life-threatening toxicity)
▶ Hyperlipidemia ▶ Rapidly progressive ascending neuromuscular weakness (rare)
▶ Renal excretion ▶ Dosage adjustment in renal insufficiency recommended
17 hrs/> 60 hrs
▶ Asthenia, headache, diarrhea, nausea, vomiting, and flatulence
▶ Renal insufficiency, Fanconi syndrome
▶ Osteomalacia ▶ Potential for decrease in bone mineral density
▶ Severe acute exacerbation of hepatitis may occur in HBV- coinfected patients who discontinue TDF
▶ Metabolized to AZT glucuronide (GAZT)
1.1 hrs/7 hrs
▶ Renal excretion of GAZT ▶ Dosage adjustment in renal insufficiency recommended
▶ Bone marrow suppression: macrocytic anemia or neutropenia
▶ Gastrointestinal intolerance, headache, insomnia, asthenia
▶ Nail pigmentation ▶ Lactic acidosis with hepatic steatosis (rare but potentially life-threatening toxicity)
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