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Key Points Î Invasive infection due to Candida species is largely a condition associated with medical progress and is widely recognized as a major cause of morbidity and mortality in the healthcare environment. Î There are at least 15 distinct Candida species that cause human disease, but over 90% of invasive disease is caused by the 5 most common pathogens, C. albicans, C. glabrata, C. tropicalis, C. parapsilosis, and C. krusei. Î Each of these organisms has unique virulence potential, antifungal susceptibility, and epidemiology. Î Taken as a whole, significant infections due to these organisms are generally referred to as "invasive candidiasis," except for mucosal Candida infections, especially those involving the oropharynx, esophagus and vagina, which are not considered to be classically invasive disease.

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