Grading System Strength of Recommendation
Grade 1 = stronga
Grade 2 = weakerb a
A = high
Quality of Evidence B = moderate C = low
Grade 1 recommendations are strong and indicate that the benefits do, or do not, outweigh risks, burden, and costs. b Grade 2 suggests that individual patient values may lead to different choices.
Abbreviations ACCP, American College of Chest Physicians; AF, atrial fibrillation; APTT, activated partial thromboplastin time; bid, twice a day; CHADS2
≥ 75, diabetes mellitus, stroke or transient ischemic attack; ClCr
deep venous thrombosis; FDA, US Food and Drug Administration; IA, intraarterial; ICH, intracerebral hemorrhage; INR, international normalized ratio; IPCD, intermittent pneumatic compression device; IV, intravenous; LMWH, low-molecular-weight heparin; MI, myocardial infarction; PO, by mouth; r-tPA, recombinant tissue plasminogen activator; STEMI, ST- segment elevation myocardial infarction; subcut, subcutaneous; TIA, transient ischemic attack; UFH, unfractionated heparin; VKA, vitamin K antagonist; VTE, venous thromboembolism
, congestive heart failure, hypertension, age , creatinine clearance; DVT,
Source Lansberg MG, O'Donnell MJ, Khatri P, Lang ES, Nguyen-Huynh MN, Schwartz NE, Sonnenberg FA, Schulman S, Vandvik PO, Spencer FA, Alonso-Coello P, Guyatt GH, Akl EA. Antithrombotic and thrombolytic therapy for ischemic stroke: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines. Chest. 2012;141(2 Suppl):e601S-e636S. doi:10.1378/chest.11-2302.
Disclaimer
This Guideline attempts to define principles of practice that should produce high-quality patient care. It focuses on the needs of primary care practice, but also is applicable to providers at all levels. This Guideline should not be considered exclusive of other methods of care reasonably directed at obtaining the same results. The ultimate judgment concerning the propriety of any course of conduct must be made by the clinician aſter consideration of each individual patient situation. Neither IGC, the medical associations, nor the authors endorse any product or service associated with the distributor of this clinical reference tool.
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