19
ATA high risk Yes
(observational
data)
Yes
(observational
data for
disease
persistence
and
recurrence)
Yes
T4
Any N
Any M
Any size, gross
extra- thyroidal
extension
ATA high risk Yes
(observational
data)
Yes
(observational
data)
Yes
M1
Any T
Any N
Distant
metastases
a
In addition to standard clinicopathologic features, local factors such as the quality of pre-operative
and post-operative ultrasound evaluations, availability and quality of thyroglobulin measurements,
experience of the operating surgeon, and clinical concerns of the local disease management team may
also be considerations in post-operative RAI decision-making.
b
Recent data from the NTCTCSG (National yroid Cancer Treatment Cooperative Study Group)
have suggested that a more appropriate prognostic age cut-off for their and other classification
systems could be 55 years, rather than 45 years, particularly for women.
Table 6. Characteristics According to the ATA Risk
Stratification System and AJCC/TNM Staging
System That May Affect Post-operative RAI
Decision-Making (cont'd)
ATA recurrence risk
Body of Evidence
Suggests
RAI Improves
Disease- Specific
Survival?
Body of
Evidence
Suggests
RAI Improves
Disease-Free
Survival?
Post-Surgical RAI
Indicated?
Staging
T N M Description
