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ACR Rheumatoid Arthritis RA Guidelines

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Recombinant vaccine Live attenuated vaccine Human Papilloma Herpes Zoster d ✔ ✔ ✔ ✔ ✔ ✔ b, e, f ✔ ✔ b, e, f ✔ ✔ ✔ ✔ ✔ Not recommended e , i ✔ Not recommended e , i f e ACR conditionally recommends giving the herpes zoster vaccine before the patient receives biologic therapy or tofacitinib for their RA in both early or established RA patients aged 50 and over. e panel also voted that aer giving the herpes zoster vaccine, there should be a 2-week waiting period before starting biologics. g Response to certain killed vaccines may be reduced aer rituximab therapy. h e ACR strongly recommends that in patients with early or established RA who are currently receiving biologics, appropriately indicated killed/inactivated vaccines should be used. i e ACR conditionally recommends that in early or established RA patients who are currently receiving biologics, live attenuated vaccines such as the herpes zoster (shingles) vaccine should not be used. 13

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