Treatment
Initial Disease
Activity
INITIAL
THERAPY
Continued Disease
Activity
Systemic JIA Without Active Systemic Features and Varying Degrees of
Figure 2. Treatment Pathways
Patient Without Active
& Varying Degrees
AJC >4
AJC >0 & ≤4
MTX or
leflunomide
NSAID
monotherapy
Intra-articular
glucocorticoid
injection
AJC >0
Disease activity
following 3
months of MTX or
leflunomide
AJC >4
Disease activity
following 1
month of NSAID
monotherapy
AJC >0 & ≤4
AJC >4
Disease activity
following initial
joint injection
AJC >0 & ≤4
C
D
D
C
