Table 4. Drugs
Drugs Brand JIA Dose
IL-6
Tocilizumab Actemra Polyarticular
• <30 mg : 10 mg/kg
• ≥30 mg : 8 mg/kg
Systemic
• <30 mg : 12 mg/kg
• ≥30 mg : 10 mg/kg
IL-1
Anakinra Kineret No FDA-approved label
Canakinumab Ilaris • ≥7.5 kg : 4 mg/kg IV subcut (Max: 300 mg ) q4wks
Rilonacept Arcalyst No FDA-approved label
Anti-TNF
Adalimumab Humira Subcut
• 10 kg to <15 kg : 10 mg every other week
• 15 kg to <30 kg : 20 mg every other week
• ≥30 kg : 40 mg every other week
Certolizumab Cimzia No FDA-approved label
Etanercept Enbrel 0.8 mg/kg subcut weekly, with a maximum of 50 mg
per week
Golimumab Simponi No FDA-approved label
Infliximab Remicade No FDA-approved label
Other Biologics
Abatacept Orencia • <75 kg : 10 mg/kg IV
• 75-100 kg : 750 mg IV
• >100 mg : 1000 mg IV
Rituximab Rituxan No FDA-approved label
Calcineurin inhibitors
Cyclosporine Neoral No FDA-approved label
Tacrolimus Prograf No FDA-approved label
DMARDs
Leflunomide Arava,
generic
• <20 kg :
PO 100 mg once, then 10 mg q2d
• 20-40 kg :
100 mg daily × 2, then 10 mg daily
• >40 mg :
100 daily × 3, then 20 mg daily
Methotrexate Rasuvo,
Otrexup
15 mg/m
2
subcut weekly
