Screening/Preventive Therapy
Figure 3. Tuberculosis (TB) Screening Algorithm for
Biologics and Tofacitinib
No Latent
or Active
TB (presume
uninfected)
d
Completion of at least 1 month
treatment for latent TB
g
Completion of treatment for
active TB
g
Start (or resume) biologic or tofacitinib immediately
D. If risk factors for
future or ongoing TB
exposure, screen annually
for latent TB
h
Positive Negative
A. Initial TST
a
or IGRA
b
Repeat/Rescreen (only
if TB risk factors
c
present)
B. Chest Radiograph
e
Positive
Negative
C. Sputum for AFB (to
rule out active TB)
f
Positive
Negative
Active TB
g
Latent TB
g
14
