Treatment Figure 2. Isolated HIT (HIT Without Thrombosis)
Normal renal function
Lepirudin, argatroban, or danaparoid* (2C)
HIT Complicated by Thrombosis
Patients with strongly suspected or confirmed HIT with thrombosis
Vitamin K if on VKA (2C) Normal renal function Renal insufficiency
Argatroban, danaparoid* or lepirudin (1C)
Give ≤ 5 mg warfarin only aſter platelets are ≥ 150 x 109
If HIT confirmed, overlap VKA with nonheparin for ≥ 5 d and until INR is within target range (1C)
nonheparin has abated (1C) Recheck INR aſter Continue VKA for 3 months * Not available in the US. /L (1C)
Argatroban (2C)
