Reperfusion and Antithrombotic Therapy Options Class/Agent
Route
Anti-platelet Aspirin
Clopidogrelb (Plavix® Prasugrel (Effient® Ticagrelor (Brilinta™
)c )c ) )
PO PO PO PO
Glycoprotein IIb/IIIa Inhibitors Abciximab (ReoPro® Eptifibatide (Integrilin® Tirofiban (Aggrastat®
) )
Thrombolytics Alteplase (Activase® Reteplase (Retavase®
) )
Streptokinase (Streptase® Urokinase (Kinlytic®
)
Anticoagulants Heparin (UFH)
Enoxaparin (LMWH) (Lovenox®
)
Dalteparin (LMWH) (Fragmin®
)
Tinzaparin (LMWH) (Innohep®
) Reviparin (LMWH)
Factor X Inhibitor Fondaparinux (Arixtra®
)
Thrombin Inhibitors Bivalirudin (Angiomax®
) )
IV IV IV
IV IV IV IV
subcut, IV
subcut, IV
subcut subcut subcut subcut IV § a Please see text for specific dose recommendations.
b FDA warning: Clopidogrel (Plavix) can be less effective in poor metabolizers. c Not FDA approved at the time of guideline publication. d Heparin-induced.
FDA Approved Indicationsa VT PE ACS PCI At Fib
Arterial Emboli
