Upper Respiratory
Rhinitis (eg, sneezing, rhinorrhea, nasal pruritus and/ or nasal congestion OR Throat-clearing (itchy throat) OR Cough perceived to come from the upper airway, not the lung, larynx or trachea
Asthma: cough, wheezing, shortness of breath (eg, less than 40% PEF or FEV1
drop,
responding to an inhaled bronchodilator)
Asthma: (eg, 40% PEF or FEV1
drop NOT
responding to an inhaled bronchodilator)
Respiratory failure with or without loss of consciousness
DEATH
a Each grade is based on the organ system involved and severity. Organ systems are defined as follows: cutaneous, conjunctival, upper respiratory, lower respiratory, gastrointestinal, cardiovascular, and other. A reaction from a single organ system, such as cutaneous, conjunctival, or upper respiratory, but not asthma, gastrointestinal, or cardiovascular, is classified as grade 1. Symptom(s)/sign(s) from more than 1 organ system or asthma, gastrointestinal, or cardiovascular are classified as grades 2 or 3. Respiratory failure or hypotension, with or without loss of consciousness, is defined as grade 4 and death as grade 5. The grade is determined by the physician's clinical judgment.
b This constellation of symptoms can rapidly progress to a more severe reaction. c Symptoms occurring within the first minutes aſter the injection might be a sign of severe anaphylaxis. Mild symptoms can progress rapidly to severe anaphylaxis and death.
d If signs or symptoms are not included in the table or the differentiation between a systemic reaction and a vasovagal (vasodepressor) reaction, which can occur with any medical intervention, is difficult, please include comment, as appropriate.
Hypotension with or without loss of consciousness
Lower Respiratory
Other
Nausea, metallic taste or headache
Gastrointestinal Cardiovascular
Uterine cramps
Abdominal cramps, vomiting or diarrhea
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